Characterization of the TPX2 Domains Involved in Microtubule Nucleation and Spindle Assembly in Xenopus Egg Extracts

TPX2 has multiple functions during mitosis, including microtubule nucleation around the chromosomes and the targeting of Xklp2 and Aurora A to the spindle. We have performed a detailed domain functional analysis of TPX2 and found that a large N-terminal domain containing the Aurora A binding peptide...

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Publicat a:Mol Biol Cell
Autors principals: Brunet, Stéphane, Sardon, Teresa, Zimmerman, Timo, Wittmann, Torsten, Pepperkok, Rainer, Karsenti, Eric, Vernos, Isabelle
Format: Artigo
Idioma:Inglês
Publicat: American Society for Cell Biology 2004
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Articles
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC532013/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15385625/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-05-0385
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