TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF) Is Essential for MPTP-Induced Dopaminergic Neuroprotection via Microglial Cell M1/M2 Modulation

Dynamic changes of two phenotypes of microglia, M1 and M2, are critically associated with the neurodegeneration of Parkinson's disease. However, the regulation of the M1/M2 paradigm is still unclear. In the MPTP induced neurodegeneration model, we examined the concentration of dopamine (DA) rel...

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Gepubliceerd in:Front Cell Neurosci
Hoofdauteurs: Shan, Minghui, Lin, Sen, Li, Shurong, Du, Yuchen, Zhao, Haixia, Hong, Huarong, Yang, Ming, Yang, Xi, Wu, Yongmei, Ren, Liyi, Peng, Jiali, Sun, Jing, Zhou, Hongli, Su, Bingyin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2017
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319955/
https://ncbi.nlm.nih.gov/pubmed/28275337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00035
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