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Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: the role of the PPARα-FGF21 axis
BACKGROUND & AIMS: Cytochrome P450 2A5 (CYP2A5) is induced by ethanol, and the ethanol induction of CYP2A5 is regulated by nuclear factor-erythroid 2-related factor 2 (NRF2). Cyp2a5 knockout (Cyp2a5(−/−)) mice develop more severe alcoholic fatty liver than Cyp2a5(+/+) mice. Fibroblast growth fac...
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| Pubblicato in: | Toxicology |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5319905/ https://ncbi.nlm.nih.gov/pubmed/28131861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2017.01.016 |
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