Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G(0)/G(1) Phase Cells

The catalytic subunit of DNA dependent protein kinase (DNA-PKcs) and its kinase activity are critical for mediation of non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSB) in mammalian cells after gamma-ray irradiation. Additionally, DNA-PKcs phosphorylations at the T2609 cluster and...

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Gepubliceerd in:Radiat Res
Hoofdauteurs: Nagasawa, Hatsumi, Lin, Yu-Fen, Kato, Takamitsu A., Brogan, John R., Shih, Hung-Ying, Kurimasa, Akihiro, Bedford, Joel S., Chen, Benjamin P. C., Little, John B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319878/
https://ncbi.nlm.nih.gov/pubmed/28118114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14679.1
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