Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer

Over 80% of triple negative breast cancers express mutant p53. Mutant p53 often gains oncogenic function suggesting that triple negative breast cancers may be driven by p53 protein type. To determine the chromatin targets of this gain-of-function mutant p53 we used inducible knockdown of endogenous...

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Veröffentlicht in:NPJ Breast Cancer
Hauptverfasser: Qiu, Wei-Gang, Polotskaia, Alla, Xiao, Gu, Di, Lia, Zhao, Yuhan, Hu, Wenwei, Philip, John, Hendrickson, Ronald C., Bargonetti, Jill
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319483/
https://ncbi.nlm.nih.gov/pubmed/28232952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-016-0001-7
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