Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriched for target genes of transcription factors...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Kar, Siddhartha P, Adler, Emily, Tyrer, Jonathan, Hazelett, Dennis, Anton-Culver, Hoda, Bandera, Elisa V, Beckmann, Matthias W, Berchuck, Andrew, Bogdanova, Natalia, Brinton, Louise, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Dansonka-Mieszkowska, Agnieszka, Doherty, Jennifer Anne, Dörk, Thilo, Dürst, Matthias, Eccles, Diana, Fasching, Peter A, Flanagan, James, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Heitz, Florian, Hildebrandt, Michelle A T, Høgdall, Estrid, Høgdall, Claus K, Huntsman, David G, Jensen, Allan, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Levine, Douglas A, Li, Qiyuan, Lissowska, Jolanta, Lu, Karen H, Lubiński, Jan, Massuger, Leon F A G, McGuire, Valerie, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Monteiro, Alvaro N, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Permuth, Jennifer B, Phelan, Catherine, Pike, Malcolm C, Poole, Elizabeth M, Ramus, Susan J, Risch, Harvey A, Rossing, Mary Anne, Salvesen, Helga B, Schildkraut, Joellen M, Sellers, Thomas A, Sherman, Mark, Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa, Terry, Kathryn L, Tworoger, Shelley S, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S, Wu, Anna H, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Freedman, Matthew L, Gayther, Simon A, Pharoah, Paul D P, Lawrenson, Kate
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Genetics & Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318969/
https://ncbi.nlm.nih.gov/pubmed/28103614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.426
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