Phase II randomised discontinuation trial of the MET/VEGF receptor inhibitor cabozantinib in metastatic melanoma

BACKGROUND: A phase II randomised discontinuation trial assessed cabozantinib (XL184), an orally bioavailable inhibitor of tyrosine kinases including VEGF receptors, MET, and AXL, in a cohort of patients with metastatic melanoma. METHODS: Patients received cabozantinib 100 mg daily during a 12-week...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Daud, Adil, Kluger, Harriet M, Kurzrock, Razelle, Schimmoller, Frauke, Weitzman, Aaron L, Samuel, Thomas A, Moussa, Ali H, Gordon, Michael S, Shapiro, Geoffrey I
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318966/
https://ncbi.nlm.nih.gov/pubmed/28103611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.419
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