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Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization

During amyloid fibril formation, amyloidogenic polypeptides misfold and self assemble into soluble pre-fibrillar aggregates, i.e., protofibrils, which elongate and mature into insoluble fibrillar aggregates. An emerging class of chaperones, chaperone-like amyloid binding proteins (CLABPs), has been...

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Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Bonito-Oliva, Alessandra, Barbash, Shahar, Sakmar, Thomas P., Graham, W Vallen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318909/
https://ncbi.nlm.nih.gov/pubmed/28220836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42880
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