C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to characterize naturally occurring mutants from tumor cells to pinpoint potential domains of RB protein crucial for tumor suppres...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shew, J Y, Lin, B T, Chen, P L, Tseng, B Y, Yang-Feng, T L, Lee, W H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53188/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1688660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.1.6
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