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Design, synthesis and evaluation of anti-CD123 antibody drug conjugates

Leukemia stem cells (LSCs) account for the development of drug resistance and increased recurrence rate in acute myeloid leukemia (AML) patients. Targeted drug delivery to leukemia stem cells remains a major challenge in AML chemotherapy. Overexpressed interleukin-3 receptor alpha chain, CD123, on t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Li, Bin, Zhao, Weiyu, Zhang, Xinfu, Wang, Junfeng, Luo, Xiao, Baker, Sharyn D., Jordan, Craig T., Dong, Yizhou
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318162/
https://ncbi.nlm.nih.gov/pubmed/27687970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.09.043
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