Design, synthesis and evaluation of anti-CD123 antibody drug conjugates

Leukemia stem cells (LSCs) account for the development of drug resistance and increased recurrence rate in acute myeloid leukemia (AML) patients. Targeted drug delivery to leukemia stem cells remains a major challenge in AML chemotherapy. Overexpressed interleukin-3 receptor alpha chain, CD123, on t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Li, Bin, Zhao, Weiyu, Zhang, Xinfu, Wang, Junfeng, Luo, Xiao, Baker, Sharyn D., Jordan, Craig T., Dong, Yizhou
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318162/
https://ncbi.nlm.nih.gov/pubmed/27687970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.09.043
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