Design, Synthesis and Evaluation of Anti-CD38 Antibody Drug Conjugate Based on Daratumumab and Maytansinoid

Daratumumab, an FDA approved antibody drug, displays specific targeting ability to abnormal white blood cells overexpressing CD38 and provides efficacious therapy for multiple myeloma. Here, in order to achieve enhanced remission of multiple myeloma, we designed Dara-DM4, antibody drug conjugates (A...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Zhang, Xinfu, Zhang, Chengxiang, Yang, Xiaomei, Hou, Xucheng, Zhao, Weiyu, Benson, Don, Yu, Jianhua, Dong, Yizhou
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339845/
https://ncbi.nlm.nih.gov/pubmed/30594452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.12.024
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