The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells

Vascular endothelial cell growth factor receptor 2 (VEGFR2) is an essential receptor for the homeostasis of endothelial cells. In this study, we showed that NEDD8-conjugated Cullin3 (CUL3)-based ubiquitin E3 (UbE3) ligase plays a crucial role in VEGFR2 mRNA expression. Human umbilical vein endotheli...

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Publicat a:Sci Rep
Autors principals: Sakaue, Tomohisa, Sakakibara, Iori, Uesugi, Takahiro, Fujisaki, Ayako, Nakashiro, Koh-ichi, Hamakawa, Hiroyuki, Kubota, Eiji, Joh, Takashi, Imai, Yu-ki, Izutani, Hironori, Higashiyama, Shigeki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317005/
https://ncbi.nlm.nih.gov/pubmed/28216678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42845
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