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A combination of mutational and computational scanning guides the design of an artificial ligand-binding controlled lipase
Allostery, i.e. the control of enzyme activity by a small molecule at a location distant from the enzyme’s active site, represents a mechanism essential for sustaining life. The rational design of allostery is a non-trivial task but can be achieved by fusion of a sensory domain, which responds to en...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5316958/ https://ncbi.nlm.nih.gov/pubmed/28218303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42592 |
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