Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

Alterations in PIK3CA, the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas. Inhibitors of PI3Kα show promising activity in various cancer types, but their use is curtailed by dose-limiting side effects such as hyperglyc...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mizrachi, Aviram, Shamay, Yosi, Shah, Janki, Brook, Samuel, Soong, Joanne, Rajasekhar, Vinagolu K., Humm, John L., Healey, John H., Powell, Simon N., Baselga, José, Heller, Daniel A., Haimovitz-Friedman, Adriana, Scaltriti, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316830/
https://ncbi.nlm.nih.gov/pubmed/28194032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14292
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