AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas

Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in squamous carcinoma (SCC) of head and neck (H&N) bearing PIK3CA mutations or amplification. Studying models of therapeutic resistance we have observed that SCCs cells that become refractory to PI3Kα inhibition maintain...

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Опубликовано в: :Cancer Cell
Главные авторы: Elkabets, Moshe, Pazarentzos, Evangelos, Juric, Dejan, Sheng, Qing, Pelossof, Raphael A., Brook, Samuel, Benzaken, Ana Oaknin, Rodon, Jordi, Morse, Natasha, Yan, Jenny Jiacheng, Liu, Manway, Das, Rita, Chen, Yan, Tam, Angela, Wang, Huiqin, Liang, Jinsheng, Gurski, Joseph M., Kerr, Darcy A., Rosell, Rafael, Teixidó, Cristina, Huang, Alan, Ghossein, Ronald A., Rosen, Neal, Bivona, Trever G., Scaltriti, Maurizio, Baselga, José
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398915/
https://ncbi.nlm.nih.gov/pubmed/25873175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.03.010
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