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The role of protein kinase C in the metabolic regulation of the cardiac Na(+) channel
BACKGROUND: NADH increases in cardiomyopathy, activates protein kinase C (PKC), upregulates mitochondrial reactive oxygen species (mitoROS), and downregulates the cardiac Na(+) channel (Na(v)1.5). OBJECTIVE: The objective was to determine how NADH signals downregulation of Na(v)1.5. METHODS: Isolate...
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| Publicado en: | Heart Rhythm |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5316355/ https://ncbi.nlm.nih.gov/pubmed/27989687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2016.12.026 |
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