Regulation of membrane type-1 matrix metalloproteinase activity and intracellular localization in clinical thoracic aortic aneurysms

OBJECTIVE: Membrane type-1 MMP (MT1-MMP) is elevated during thoracic aortic aneurysm (TAA) development in mouse models, and plays an important role in the activation of MMP-2 and the release of matrix bound TGF-β. This study tested the hypothesis that MT1-MMP is subject to protein kinase C (PKC)-med...

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Vydáno v:J Thorac Cardiovasc Surg
Hlavní autoři: Ikonomidis, John S., Nadeau, Elizabeth K., Akerman, Adam W., Stroud, Robert E., Mukherjee, Rupak, Jones, Jeffrey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316335/
https://ncbi.nlm.nih.gov/pubmed/27923483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2016.10.065
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