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Differential Effect of Wall Tension on Matrix Metalloproteinase Promoter Activation in the Thoracic Aorta

BACKGROUND: Vascular remodeling relies upon extracellular matrix restructuring by the matrix metalloproteinases (MMPs). Induction of MMP-2 and MMP-9 by biological signaling molecules has been defined, but whether a mechanical stimulus such as elevated wall tension may generate MMP promoter activatio...

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Autores principales: Ruddy, Jean Marie, Jones, Jeffrey A., Stroud, Robert E., Mukherjee, Rupak, Spinale, Francis G., Ikonomidis, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859117/
https://ncbi.nlm.nih.gov/pubmed/19375723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2008.12.033
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