IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes

Lithium is the prototype mood stabilizer but its mechanism is still unresolved. Two hypotheses dominate—the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the ‘inositol depletion' hypothesis), and of glycogen-synthase kinase-3....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Transl Psychiatry
Egile Nagusiak: Sade, Y, Toker, L, Kara, N Z, Einat, H, Rapoport, S, Moechars, D, Berry, G T, Bersudsky, Y, Agam, G
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315558/
https://ncbi.nlm.nih.gov/pubmed/27922641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.217
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