IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes

Lithium is the prototype mood stabilizer but its mechanism is still unresolved. Two hypotheses dominate—the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the ‘inositol depletion' hypothesis), and of glycogen-synthase kinase-3....

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Publicat a:Transl Psychiatry
Autors principals: Sade, Y, Toker, L, Kara, N Z, Einat, H, Rapoport, S, Moechars, D, Berry, G T, Bersudsky, Y, Agam, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315558/
https://ncbi.nlm.nih.gov/pubmed/27922641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.217
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