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VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites
Developmental checkpoints eliminate B cells synthesizing defective immunoglobulin heavy (HC) and light (LC) chains. The first checkpoint tests for formation of a VpreB/λ5/µHC-containing preB-cell receptor (preBCR) and predicts whether µHCs will bind conventional LCs to form membrane IgM. VpreB and λ...
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| Publicado no: | Sci Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5315267/ https://ncbi.nlm.nih.gov/pubmed/28217764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf6628 |
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