The pre-B-cell receptor induces silencing of VpreB and λ5 transcription

The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals downregulation of the SLC genes (VpreB and λ5), thereby limiting this expansion. We demonstrate that, as BM cel...

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Détails bibliographiques
Auteurs principaux: Parker, Mathew J, Licence, Steve, Erlandsson, Lena, Galler, Gunther R, Chakalova, Lyubomira, Osborne, Cameron S, Morgan, Geoff, Fraser, Peter, Jumaa, Hassan, Winkler, Thomas H, Skok, Jane, Mårtensson, Inga-Lill
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283949/
https://ncbi.nlm.nih.gov/pubmed/16281060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600850
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