CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Targeting translation initiation is an emerging anti-neoplastic strategy that capitalizes on de-regulated upstream MAPK and PI3K-mTOR signaling pathways in cancers. A key regulator of translation that controls ribosome recruitment flux is eukaryotic initiation factor (eIF) 4F, a hetero-trimeric comp...

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Publicado en:Cell Rep
Autores principales: Chu, Jennifer, Galicia-Vázquez, Gabriela, Cencic, Regina, Mills, John R., Katigbak, Alexandra, Porco, John A., Pelletier, Jerry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315212/
https://ncbi.nlm.nih.gov/pubmed/27239032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.005
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