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Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation
Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT and TFB2M to melt the promoter. However, we show that TFAM has ‘post-recruitment’ roles in promoter melting and RNA synthe...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5314767/ https://ncbi.nlm.nih.gov/pubmed/27903899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1157 |
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