Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

Homologous recombination (HR) is a crucial pathway for double-stranded DNA break (DSB) repair. During the early stages of HR, the newly generated DSB ends are processed to yield long single-stranded DNA (ssDNA) overhangs, which are quickly bound by replication protein A (RPA). RPA is then replaced b...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ma, Chu Jian, Gibb, Bryan, Kwon, YoungHo, Sung, Patrick, Greene, Eric C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314761/
https://ncbi.nlm.nih.gov/pubmed/27903895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1125
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