C (3)-symmetric opioid scaffolds are pH-responsive DNA condensation agents

Herein we report the synthesis of tripodal C(3)-symmetric opioid scaffolds as high-affinity condensation agents of duplex DNA. Condensation was achieved on both supercoiled and canonical B-DNA structures and identified by agarose electrophoresis, viscosity, turbidity and atomic force microscopy (AFM...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: McStay, Natasha, Molphy, Zara, Coughlan, Alan, Cafolla, Attilio, McKee, Vickie, Gathergood, Nicholas, Kellett, Andrew
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2017
Ämnen:
Chemical Biology and Nucleic Acid Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314759/
https://ncbi.nlm.nih.gov/pubmed/27899572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1097
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