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Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination

In order to expand the current repertoire of cancer treatments and to help circumvent limitations associated with resistance, the identification of new metallodrugs with high potency and novel mechanisms of action is of significant importance. Here we present a class of di-copper(II) complex based o...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Slator, Creina, Molphy, Zara, McKee, Vickie, Long, Conor, Brown, Tom, Kellett, Andrew
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888725/
https://ncbi.nlm.nih.gov/pubmed/29474633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky105
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