Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein

BACKGROUND: The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env), a Type 1 transmembrane protein, assembles into a trimeric spike complex that mediates virus entry into host cells. The high potential energy of the metastable, unliganded Env trimer is maintained by multiple non-covale...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Nguyen, Hanh T., Madani, Navid, Ding, Haitao, Elder, Emerald, Princiotto, Amy, Gu, Christopher, Darby, Patrice, Alin, James, Herschhorn, Alon, Kappes, John C., Mao, Youdong, Sodroski, Joseph G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314615/
https://ncbi.nlm.nih.gov/pubmed/28209172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0704-x
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