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Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity

Septic patients experience chronic immunosuppression resulting in enhanced susceptibility to infections normally controlled by T cells. Clinical research on septic patients has shown increased apoptosis and reduced total numbers of CD4 and CD8 T cells, suggesting contributing mechanism driving immun...

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Bibliographic Details
Published in:Crit Rev Immunol
Main Authors: Danahy, Derek B., Strother, Robert K., Badovinac, Vladimir P., Griffith, Thomas S.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314458/
https://ncbi.nlm.nih.gov/pubmed/27480902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1615/CritRevImmunol.2016017098
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