UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119

UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7. We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A ubiquitination and gene silencing. We demonstrate that UbE2E1 is critical for the monoubi...

全面介紹

Na minha lista:
書目詳細資料
發表在:J Biol Chem
Main Authors: Wheaton, Keith, Sarkari, Feroz, Stanly Johns, Beena, Davarinejad, Hossein, Egorova, Olga, Kaustov, Lilia, Raught, Brian, Saridakis, Vivian, Sheng, Yi
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2017
主題:
Enzymology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314184/
https://ncbi.nlm.nih.gov/pubmed/28073915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749564
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍