UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119

UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7. We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A ubiquitination and gene silencing. We demonstrate that UbE2E1 is critical for the monoubi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wheaton, Keith, Sarkari, Feroz, Stanly Johns, Beena, Davarinejad, Hossein, Egorova, Olga, Kaustov, Lilia, Raught, Brian, Saridakis, Vivian, Sheng, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314184/
https://ncbi.nlm.nih.gov/pubmed/28073915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749564
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