Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain

All vertebrate cell surfaces display a dense glycan layer often terminated with sialic acids, which have multiple functions due to their location and diverse modifications. The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), t...

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Publicado no:J Biol Chem
Principais autores: Naito-Matsui, Yuko, Davies, Leela R. L., Takematsu, Hiromu, Chou, Hsun-Hua, Tangvoranuntakul, Pam, Carlin, Aaron F., Verhagen, Andrea, Heyser, Charles J., Yoo, Seung-Wan, Choudhury, Biswa, Paton, James C., Paton, Adrienne W., Varki, Nissi M., Schnaar, Ronald L., Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314156/
https://ncbi.nlm.nih.gov/pubmed/28049733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768531
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