N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution

Humans and chimpanzees share >99% identity in most proteins. One rare difference is a human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc). Since Neu5Gc is prominent on most chimpanzee cell surfaces, this mutati...

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Autores principales: Hedlund, Maria, Tangvoranuntakul, Pam, Takematsu, Hiromu, Long, Jeffrey M., Housley, Gary D., Kozutsumi, Yasunori, Suzuki, Akemi, Wynshaw-Boris, Anthony, Ryan, Allen F., Gallo, Richard L., Varki, Nissi, Varki, Ajit
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900035/
https://ncbi.nlm.nih.gov/pubmed/17420276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00379-07
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