Ascofuranone inhibits lipopolysaccharide–induced inflammatory response via NF-kappaB and AP-1, p-ERK, TNF-α, IL-6 and IL-1β in RAW 264.7 macrophages

The natural fungal compound ascofuranone (5-chloro-3-[(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxo-tetrahydrofuran-2-yl]-3-methyl-octa-2,6-dienyl]-2,4-dihydroxy-6-methyl-benzaldehyde, MW 420.93) (AF) isolated from Ascochyta viciae has been known to promote cell cycle arrest and inhibit invasion of tumor cells...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Park, Jun-Young, Chung, Tae-Wook, Jeong, Yun-Jeong, Kwak, Choong-Hwan, Ha, Sun-Hyung, Kwon, Kyung-Min, Abekura, Fukushi, Cho, Seung-Hak, Lee, Young-Choon, Ha, Ki-Tae, Magae, Junji, Chang, Young-Chae, Kim, Cheorl-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313137/
https://ncbi.nlm.nih.gov/pubmed/28207754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171322
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