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Tuning chromosomal instability to optimize tumor fitness
Low rates of chromosomal instability (CIN) are weakly tumor promoting while high rates of CIN cause cell death and tumor suppression. In this context, Sansregret et al show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the Anaphase Promoting...
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| Published in: | Cancer Discov |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5312840/ https://ncbi.nlm.nih.gov/pubmed/28167614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1415 |
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