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Epigenomic inactivation of RasGAPs activates Ras signaling in a subset of luminal B breast cancers
Invasion and metastasis of a subset of aggressive Lumina B breast cancers is driven by the concomitant inactivation of the Ras-GAPs, DAB2IP and RASAL2. Inactivation of both proteins increases Ras activity and drives invasion while inactivation of DAB2IP specifically promotes NF-kB mediated EMT
Guardat en:
| Publicat a: | Cancer Discov |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5312830/ https://ncbi.nlm.nih.gov/pubmed/28167613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1423 |
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