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A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis
The structural flexibility or ‘breathing’ of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at...
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| Publicat a: | PLoS Pathog |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5312798/ https://ncbi.nlm.nih.gov/pubmed/28207910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006178 |
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