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A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis

The structural flexibility or ‘breathing’ of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at...

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Bibliografske podrobnosti
izdano v:PLoS Pathog
Main Authors: Goo, Leslie, VanBlargan, Laura A., Dowd, Kimberly A., Diamond, Michael S., Pierson, Theodore C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312798/
https://ncbi.nlm.nih.gov/pubmed/28207910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006178
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