The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming

Metastasis is the major cause of death in cancer patients, yet the genetic and epigenetic programs that drive metastasis are poorly understood. Here, we report an epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by th...

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Udgivet i:Cell Rep
Main Authors: Cunha, Stéphanie, Lin, Yi-Chun, Goossen, Elizabeth A., DeVette, Christa I., Albertella, Mark R., Thomson, Stuart, Mulvihill, Mark J., Welm, Alana L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312658/
https://ncbi.nlm.nih.gov/pubmed/24388747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.010
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