Integration of population-level genotype data with functional annotation reveals over-representation of long non-coding RNAs at ovarian cancer susceptibility loci

BACKGROUND: Genome wide association studies (GWAS) have identified multiple loci associated with epithelial ovarian cancer (EOC) susceptibility, but further progress requires integration of epidemiology and biology to illuminate true risk loci below genome-wide significance levels (P<5×10(−8)). M...

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Publicado no:Cancer Epidemiol Biomarkers Prev
Main Authors: Reid, Brett M., Permuth, Jennifer B., Chen, Y. Ann, Teer, Jamie K., Monteiro, Alvaro N.A., Chen, Zhihua, Tyrer, Jonathan, Berchuck, Andrew, Chenevix-Trench, Georgia, Doherty, Jennifer A., Goode, Ellen L., Iverson, Edwin S., Lawrenson, Kate, Pearce, Celeste L., Pharoah, Paul D., Phelan, Catherine M., Ramus, Susan J., Rossing, Mary Anne, Schildkraut, Joellen M., Cheng, Jin Q., Gayther, Simon A., Sellers, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312656/
https://ncbi.nlm.nih.gov/pubmed/28035019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-16-0341
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