The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation

BACKGROUND: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling including induction of e...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: White, Martyn K., Bellizzi, Anna, Ibba, Gabriele, Pietropaolo, Valeria, Palamara, Anna T., Wollebo, Hassen S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312431/
https://ncbi.nlm.nih.gov/pubmed/28202068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0707-7
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