Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells

Missense mutation of tumor suppressor p53, which exhibits oncogenic gain-of-function (GOF), not only promotes tumor progression, but also diminishes therapeutic efficacies of cancer treatments. However, it remains unclear how a p53 missense mutant contributes to induced pluripotency of cancer stem c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hosain, Salman B., Khiste, Sachin K., Uddin, Mohammad B., Vorubindi, Vindya, Ingram, Catherine, Zhang, Sifang, Hill, Ronald A., Gu, Xin, Liu, Yong-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312403/
https://ncbi.nlm.nih.gov/pubmed/27517620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11169
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