Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

The aberrant epigenetic silencing of tumor suppressor genes (TSGs) plays a major role during carcinogenesis and regaining these dormant functions by engineering of sequence-specific epigenome editing tools offers a unique opportunity for targeted therapies. However, effectively normalizing the expre...

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Udgivet i:Oncotarget
Main Authors: Garcia-Bloj, Benjamin, Moses, Colette, Sgro, Agustin, Plani-Lam, Janice, Arooj, Mahira, Duffy, Ciara, Thiruvengadam, Shreyas, Sorolla, Anabel, Rashwan, Rabab, Mancera, Ricardo L., Leisewitz, Andrea, Swift-Scanlan, Theresa, Corvalan, Alejandro H., Blancafort, Pilar
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312401/
https://ncbi.nlm.nih.gov/pubmed/27528034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11142
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