Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. NSCLC development and progression have recently been correlated with the heightened activation of histone deacetylases (HDACs) and PI3K/Akt signaling pathways. Targeted inhibition of these proteins is promisin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Piao, Junjie, Chen, Liyan, Quan, Taihao, Li, Longshan, Quan, Chunji, Piao, Yingshi, Jin, Tiefeng, Lin, Zhenhua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312376/
https://ncbi.nlm.nih.gov/pubmed/27507059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11109
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