Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells

Both dichloroacetate (DCA) and metformin (Met) have shown promising antitumor efficacy by regulating cancer cell metabolism. However, the DCA-mediated protective autophagy and Met-induced lactate accumulation limit their tumor-killing potential respectively. So overcoming the corresponding shortages...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Bo, Li, Xinzhe, Ni, Zhenhong, Zhang, Yan, Zeng, Yijun, Yan, Xiaohuan, Huang, Yan, He, Jintao, Lyu, Xilin, Wu, Yaran, Wang, Yuting, Zheng, Yingru, He, Fengtian
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312324/
https://ncbi.nlm.nih.gov/pubmed/27449090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10694
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