Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells

Both dichloroacetate (DCA) and metformin (Met) have shown promising antitumor efficacy by regulating cancer cell metabolism. However, the DCA-mediated protective autophagy and Met-induced lactate accumulation limit their tumor-killing potential respectively. So overcoming the corresponding shortages...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Li, Bo, Li, Xinzhe, Ni, Zhenhong, Zhang, Yan, Zeng, Yijun, Yan, Xiaohuan, Huang, Yan, He, Jintao, Lyu, Xilin, Wu, Yaran, Wang, Yuting, Zheng, Yingru, He, Fengtian
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312324/
https://ncbi.nlm.nih.gov/pubmed/27449090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10694
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