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TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: A potential novel approach to the treatment of metastatic colorectal cancer

It is now widely accepted that therapeutic antibodies targeting epidermal growth factor receptor (EGFR) can have efficacy in KRAS wild-type advanced colorectal cancer (CRC) patients. What remains to be ascertained is whether a subgroup of KRAS-mutated CRC patients might not also derive benefit from...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tarpgaard, Line S., Ørum-Madsen, Maj Sofie, Christensen, Ib J., Nordgaard, Cathrine, Noer, Julie, Guren, Tormod K., Glimelius, Bengt, Sorbye, Halfdan, Ikdahl, Tone, Kure, Elin H., Tveit, Kjell M., Nielsen, Hans J., Pfeiffer, Per, Brünner, Nils, Moreira, José M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312323/
https://ncbi.nlm.nih.gov/pubmed/27509063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11118
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