FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab

BACKGROUND: Polymorphisms of genes encoding the Fcy receptors (Fc fragment of IgG receptor 2A (FCGR2A) and 3A (FCGR3A)), which influence their affinity for the Fc fragment, have been linked to the pharmacodynamics of monoclonal antibodies. Most studies have been limited by small samples sizes and ha...

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Autors principals: Kjersem, Janne B, Skovlund, Eva, Ikdahl, Tone, Guren, Tormod, Kersten, Christian, Dalsgaard, Astrid M, Yilmaz, Mette K, Fokstuen, Tone, Tveit, Kjell M, Kure, Elin H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045863/
https://ncbi.nlm.nih.gov/pubmed/24884501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-340
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