FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab

BACKGROUND: Polymorphisms of genes encoding the Fcy receptors (Fc fragment of IgG receptor 2A (FCGR2A) and 3A (FCGR3A)), which influence their affinity for the Fc fragment, have been linked to the pharmacodynamics of monoclonal antibodies. Most studies have been limited by small samples sizes and ha...

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Autori principali: Kjersem, Janne B, Skovlund, Eva, Ikdahl, Tone, Guren, Tormod, Kersten, Christian, Dalsgaard, Astrid M, Yilmaz, Mette K, Fokstuen, Tone, Tveit, Kjell M, Kure, Elin H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045863/
https://ncbi.nlm.nih.gov/pubmed/24884501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-340
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