Let-7 miRNA-binding site polymorphism in the KRAS 3(′)UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab

BACKGROUND: Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site (LCS6) within the 3(′)untranslated region (3(′)UTR) of KRAS (rs61764370) and clinical outcome in metastatic colorectal cancer (mCRC) patients receiving cetuximab. The variant allele...

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Main Authors: Kjersem, Janne B, Ikdahl, Tone, Guren, Tormod, Skovlund, Eva, Sorbye, Halfdan, Hamfjord, Julian, Pfeiffer, Per, Glimelius, Bengt, Kersten, Christian, Solvang, Hiroko, Tveit, Kjell M, Kure, Elin H
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526507/
https://ncbi.nlm.nih.gov/pubmed/23167843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-534
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